Basic concepts for sample size calculation: Critical step for any clinical trials!
نویسندگان
چکیده
منابع مشابه
A mixed Bayesian/Frequentist approach in sample size determination problem for clinical trials
In this paper we introduce a stochastic optimization method based ona mixed Bayesian/frequentist approach to a sample size determinationproblem in a clinical trial. The data are assumed to come from a nor-mal distribution for which both the mean and the variance are unknown.In contrast to the usual Bayesian decision theoretic methodology, whichassumes a single decision maker, our method recogni...
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Addressing a sample size is a practical issue that has to be solved during planning and designing stage of the study. The aim of any clinical research is to detect the actual difference between two groups (power) and to provide an estimate of the difference with a reasonable accuracy (precision). Hence, researchers should do a priori estimate of sample size well ahead, before conducting the stu...
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An outcome variable is one which we hope to change, predict or estimate in a trial. Examples: • Systolic blood pressure in a hypertension trial • Caesarean section rate in an obstetric trial • Survival time in a cancer trial How many outcome variables should I have? If we have many outcome variables: • all possibilities would be covered, • we would be less likely to miss something, • the risk o...
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BACKGROUND Cluster-randomized trials, in which health interventions are allocated randomly to intact clusters or communities rather than to individual subjects, are increasingly being used to evaluate disease control strategies both in industrialized and in developing countries. Sample size computations for such trials need to take into account between-cluster variation, but field epidemiologis...
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introduction: the purpose of this article was to evaluate the quality of sample size calculation reports in published clinical trials in journal of endodontics and international endodontic journal in years 2000-1 and 2009-10. materials and methods: articles fulfilling the inclusion criteria were collected. the criteria were: publication year, research design, types of control group, reporting s...
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ژورنال
عنوان ژورنال: Saudi Journal of Anaesthesia
سال: 2016
ISSN: 1658-354X
DOI: 10.4103/1658-354x.174918